Image Analysis: A Versatile Tool in the Manufacturing and Quality Control of Pharmaceutical Dosage Forms

被引:17
|
作者
Farkas, Dora [1 ]
Madarasz, Lajos [2 ]
Nagy, Zsombor K. [2 ]
Antal, Istvan [1 ]
Kallai-Szabo, Nikolett [1 ]
机构
[1] Semmelweis Univ, Dept Pharmaceut, Hogyes Str 7, H-1092 Budapest, Hungary
[2] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, Muegyet Rakpart 3, H-1111 Budapest, Hungary
关键词
image analysis; pharmaceutical dosage form; foam; particle size; shape parameters; LASER-SCANNING MICROSCOPY; PARTICLE-SIZE; COATING THICKNESS; PROCESSING CONDITIONS; PELLET-DISTRIBUTION; SURFACE-TENSION; PENDANT DROP; DRUG-RELEASE; O/W CREAMS; TABLETS;
D O I
10.3390/pharmaceutics13050685
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In pharmaceutical sciences, visual inspection is one of the oldest methods used for description in pharmacopeias and is still an important part of the characterization and qualification of active ingredients, excipients, and dosage forms. With the development of technology, it is now also possible to take images of various pharmaceutical dosage forms with different imaging methods in a size range that is hardly visible or completely invisible to the human eye. By analyzing high-quality designs, physicochemical processes can be understood, and the results can be used even in the optimization of the composition of the dosage form and in the development of its production. The present study aims to show some of the countless ways image analysis can be used in the manufacturing and quality assessment of different dosage forms. This summary also includes measurements and an evaluation of, amongst others, a less studied dosage form, medicated foams.
引用
收藏
页数:22
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