Role of the Y-Family DNA Polymerases YqjH and YqjW in Protecting Sporulating Bacillus subtilis Cells from DNA Damage

被引：23

作者：

Rivas-Castillo, Andrea M. ^{[1
]}

Yasbin, Ronald E. ^{[2
]}

Robleto, E. ^{[2
]}

Nicholson, Wayne L. ^{[3
]}

Pedraza-Reyes, Mario ^{[1
]}

机构：

[1] Univ Guanajuato, Dept Biol, Div Nat & Exact Sci, Guanajuato 36050, Gto, Mexico

[2] Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA

[3] Univ Florida, Space Life Sci Lab, Dept Microbiol & Cell Sci, Kennedy Space Ctr, FL 32899 USA

来源：

CURRENT MICROBIOLOGY | 2010年 / 60卷 / 04期

基金：

美国国家科学基金会;

关键词：

MUTAGENESIS; RESISTANCE; RADIATION; GENE;

D O I：

10.1007/s00284-009-9535-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role played by the Y-family DNA polymerases YqjH and YqjW in protecting sporulating cells of Bacillus subtilis from DNA damage was determined. The absence of either yqjH and/or yqjW not only reduced sporulation efficiency but also sensitized the sporulating cells to hydrogen peroxide, tert-butylhydroperoxide (t-BHP), mitomycin-C (M-C), and UV-C radiation. Moreover, these DNA-damaging agents increased the mutation frequency of wild-type sporulating cells to 4-azaleucine, but the production of mutants was YqjH- and YqjW-dependent. In conclusion, the results presented here indicate that YqjH/YqjW-dependent-translesion synthesis (TLS) operates in sporulating B. subtilis cells and contributes in processing spontaneous and artificially induced genetic damage, which is apparently required for an efficient sporulation process.

引用

页码：263 / 267

页数：5

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