Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel

被引:13
|
作者
Spurney, Christopher F. [1 ]
Ascheim, Deborah [2 ]
Charnas, Lawrence [3 ]
Cripe, Linda [4 ]
Hor, Kan [4 ]
King, Nicholas [5 ]
Kinnett, Kathi [6 ]
McNally, Elizabeth M. [7 ]
Sauer, John-Michael [5 ]
Sweeney, Lee [8 ]
Villa, Chet [9 ]
Markham, Larry W. [10 ]
机构
[1] Childrens Natl Hosp, Childrens Natl Heart Inst, Washington, DC 20010 USA
[2] D2A, Los Angeles, CA USA
[3] Pfizer, Clin Res Rare Neurol Dis, Cambridge, MA USA
[4] Nationwide Childrens Hosp, Heart Ctr, Columbus, OH USA
[5] Crit Path Inst, Tucson, AZ USA
[6] Parent Project Muscular Dystrophy, Hackensack, NJ USA
[7] Northwestern Med, Ctr Genet Med, Chicago, IL USA
[8] Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL USA
[9] Cincinnati Childrens Hosp Med Ctr, Cardiol, Cincinnati, OH 45229 USA
[10] Indiana Univ Hlth, Riley Hosp Children, Pediat, Div Pediat Cardiol, Indianapolis, IN USA
来源
OPEN HEART | 2021年 / 8卷 / 01期
关键词
biomarkers; genetic diseases; inborn; cardiomyopathy; dilated;
D O I
10.1136/openhrt-2021-001592
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiac disease is now the leading cause of death in Duchenne muscular dystrophy (DMD). Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunction in DMD. Clinicians require a better understanding of the relationship of symptoms, troponin levels and progression of cardiac disease in DMD. As clinical trials begin to assess novel cardiac therapeutics in DMD, troponin levels in DMD are important for safety monitoring and outcome measures. The Parent Project Muscular Dystrophy convened an expert panel of cardiologists, scientists, and regulatory and industry specialists on 16 December 2019 in Silver Spring, Maryland and reviewed published and unpublished data from their institutions. The panel recommended retrospective troponin data analyses, prospective longitudinal troponin collection using high-sensitivity cardiac troponin I assays, inclusion of troponin in future clinical trial outcomes and future development of clinical guidelines for monitoring and treating troponin elevations in DMD.
引用
收藏
页数:9
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