CARDIOMYOPATHY OF DUCHENNE MUSCULAR DYSTROPHY: CURRENT UNDERSTANDING AND FUTURE DIRECTIONS

被引：113
|
作者：
Spurney, Christopher F. [1 ]
机构：
[1] Childrens Natl Med Ctr, Med Genet Res Ctr, Div Cardiol, Washington, DC 20010 USA
来源：
MUSCLE & NERVE | 2011年 / 44卷 / 01期
关键词：
LEFT-VENTRICULAR FUNCTION; CONJUGATED MORPHOLINO OLIGOMERS; LINKED DILATED CARDIOMYOPATHY; HOME NOCTURNAL VENTILATION; IMPROVES CARDIAC-FUNCTION; MAGNETIC-RESONANCE; HEART-FAILURE; MDX MICE; NATRIURETIC PEPTIDE; FOLLOW-UP;
D O I：
10.1002/mus.22097
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy and occurs in 1 in 3500 male births. Improved survival due to improvements in clinical care of the musculoskeletal and respiratory systems has led to an increased incidence of cardiomyopathy. Cardiac-related deaths are now seen in approximately 20% of DMD patients. Our current understanding of DMD cardiomyopathy has increased significantly over the past 10 years, but further research is required to improve cardiac treatment and outcomes in DMD. This review provides a summary of the current literature and discussion of potential new therapies for DMD cardiomyopathy. Muscle Nerve 44: 8-19, 2011
引用
收藏
页码：8 / 19
页数：12
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