Continuous glucose monitoring in obese pregnant women with no hyperglycemia on glucose tolerance test

被引:6
|
作者
Rahmi, Rosa Maria [1 ]
de Oliveira, Priscila [2 ]
Selistre, Luciano [3 ]
Rezende, Paulo Cury [4 ]
Pezzella, Gabriela Neuvald [5 ]
dos Santos, Pamela Antoniazzi [6 ]
Pereira Vergani, Daiane de Oliveira [7 ]
Cabral Madi, Sonia Regina [8 ]
Madi, Jose Mauro [8 ]
机构
[1] Caxias Do Sul Univ, Gen Hosp Caxias Do Sul, Dept Endocrinol, Caxias Do Sul, RS, Brazil
[2] Caxias Do Sul Univ, Hlth Sci, Caxias Do Sul, RS, Brazil
[3] Gen Hosp Caxias Do Sul, Dept Nephrol, Caxias Do Sul, RS, Brazil
[4] Univ Sao Paulo, Med Sch, Heart Inst, Dept Atherosclerosis, Sao Paulo, SP, Brazil
[5] Caxias Do Sul Univ, Inst Sci Initiat Scholarship Program, Caxias Do Sul, RS, Brazil
[6] Caxias Do Sul Univ, Dept Nutr, Caxias Do Sul, RS, Brazil
[7] Caxias Do Sul Univ, Dept Nursing, Caxias Do Sul, RS, Brazil
[8] Caxias Do Sul Univ, Gen Hosp Caxias Do Sul, Dept Obstet & Gynecol, Caxias Do Sul, RS, Brazil
来源
PLOS ONE | 2021年 / 16卷 / 06期
关键词
GESTATIONAL DIABETES-MELLITUS; MATERNAL OBESITY; OUTCOMES;
D O I
10.1371/journal.pone.0253047
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Objective The objective of the present study was to compare 24-hour glycemic levels between obese pregnant women with normal glucose tolerance and non-obese pregnant women. Methods In the present observational, longitudinal study, continuous glucose monitoring was performed in obese pregnant women with normal oral glucose tolerance test with 75 g of glucose between the 24(th) and the 28(th) gestational weeks. The control group (CG) consisted of pregnant women with normal weight who were selected by matching the maternal age and parity with the same characteristics of the obese group (OG). Glucose measurements were obtained during 72 hours. Results Both the groups were balanced in terms of baseline characteristics (age: 33.5 [28.7-36.0] vs. 32.0 [26.0-34.5] years, p = 0.5 and length of pregnancy: 25.0 [24.0-25.0] vs. 25.5 [24.0-28.0] weeks, p = 0.6 in the CG and in the OG, respectively). Pre-breakfast glycemic levels were 77.77 10.55 mg/dL in the CG and 82.02 +/- 11.06 mg/dL in the OG (p<0.01). Glycemic levels at 2 hours after breakfast were 87.31 <plus/minus> 13.10 mg/dL in the CG and 93.48 +/- 18.74 mg/dL in the OG (p<0.001). Daytime blood glucose levels were 87.6 <plus/minus> 15.4 vs. 93.1 +/- 18.3 mg/dL (p<0.001) and nighttime blood glucose levels were 79.3 <plus/minus> 15.8 vs. 84.7 +/- 16.3 mg/dL (p<0.001) in the CG and in the OG, respectively. The 24-hour, daytime, and nighttime values of the area under the curve were higher in the OG when compared with the CG (85.1 <plus/minus> 0.16 vs. 87.9 +/- 0.12, 65.6 +/- 0.14 vs. 67.5 +/- 0.10, 19.5 +/- 0.07 vs. 20.4 +/- 0.05, respectively; p<0.001). Conclusion The results of the present study showed that obesity in pregnancy was associated with higher glycemic levels even in the presence of normal findings on glucose tolerance test.
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页数:10
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