Diagnosis and Management of DNA Mismatch Repair-Deficient Colorectal Cancer

被引：20
|
作者：
Stadler, Zsofia K. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Clin Genet Serv, Dept Med, New York, NY 10065 USA
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 01期
关键词：
Microsatellite instability; Mismatch repair deficiency; Colorectal cancer prognosis; TUMOR MICROSATELLITE-INSTABILITY; REVISED BETHESDA GUIDELINES; GENETIC TESTING STRATEGIES; LYNCH-SYNDROME; COLON-CANCER; ADJUVANT THERAPY; INSTITUTE WORKSHOP; COST-EFFECTIVENESS; CELL-LINES; CHEMOTHERAPY;
D O I：
10.1016/j.hoc.2014.09.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal tumors exhibiting defective DNA mismatch repair (MMR-D)/microsatellite instability (MSI-H) form a distinct subgroup of CRCs associated with important clinical and pathologic features. The identification of MMR-D/MSI-H may impact CRC prognosis, prediction of response to chemotherapeutic agents, and may necessitate the need for genetic assessment for Lynch syndrome. Oncologists remain at the forefront of diagnosing, treating, and managing patients with MMR-D/MSI-H CRC and ensuring that the clinical care of these patients reflect our evolving understanding of this unique CRC subtype.
引用
收藏
页码：29 / +
页数：14
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