Tumor-associated macrophages press the angiogenic switch in breast cancer

被引：347
|
作者：
Lin, Elaine Y.
Pollard, Jeffrey W.
机构：
[1] Albert Einstein Coll Med, Ctr Reprod Biol & Womens Hlth, Dept Dev & Mol Biol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Albert Einstein Canc Ctr, Dept Med, Div Oncol, Bronx, NY 10461 USA
来源：
CANCER RESEARCH | 2007年 / 67卷 / 11期
关键词：
D O I：
10.1158/0008-5472.CAN-07-0912
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
引用
收藏
页码：5064 / 5066
页数：3
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