The shifting shape of genomes: dynamics of heterochromatin interactions at the nuclear lamina

被引：20
|
作者：
Hoskins, Victoria E. [1 ,4 ]
Smith, Kristiana [1 ]
Reddy, Karen L. [1 ,2 ,3 ]
机构：
[1] Johns Hopkins Univ, Ctr Epigenet, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Sidney Kimmel Canc Inst, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[4] UNC Sch Med, Chapel Hill, NC 27599 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2021年 / 67卷
关键词：
PERIPHERAL HETEROCHROMATIN; STRUCTURAL ORGANIZATION; DOMAIN ORGANIZATION; PHASE-SEPARATION; CHROMATIN; ARCHITECTURE; A/C; METHYLATION; TRANSCRIPTION; PRINCIPLES;
D O I：
10.1016/j.gde.2021.02.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The nucleus is a highly structured organelle with many chromatin and protein compartments that partition the genome into regulatory domains. One such a compartment within the mammalian nucleus is the microenvironment underlying the nuclear envelope (NE) where intermediate filament proteins, lamins, act as a link between cytoskeletal and inner nuclear membrane (INM) proteins, chromatin binders and modifiers, and heterochromatin. These dynamic interactions regulate many cellular processes and, when they are perturbed, can lead to genome dysregulation and disease.
引用
收藏
页码：163 / 173
页数：11
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