Limonoids from seeds of Azadirachta indica A. Juss. and their cytotoxic activity

被引：0

作者：

Chen, Jian ^{[1
]}

Fan, Xiaona ^{[2
]}

Zhu, Jianhua ^{[1
]}

Song, Liyan ^{[1
]}

Li, Zhiwei ^{[1
]}

Lin, Fei ^{[3
]}

Yu, Rongmin ^{[1
]}

Xu, Hanhong ^{[3
]}

Zi, Jiachen ^{[1
]}

机构：

[1] Jinan Univ, Biotechnol Inst Chinese Mat Med, Guangzhou 510632, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China

[3] South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou 510642, Guangdong, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2018年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Azadirachta indica; Nortriterpenoid; Limonoid; Spectroscopy; Cytotoxic activity; BRAZILIAN MELIA-AZEDARACH; NIMBOLIDE; NEEM; INHIBITION; ANTIMALARIAL; APOPTOSIS; PATHWAY; CELLS;

D O I：

10.1016/j.apsh.2017.12.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Four new limonoid-type nortriterpenoids, 1-detigloyl-1-O-methacryloylsalannin (1), 28-deoxo-2,3-dihydronimbolide (2), 12-acetoxy-3-0-acetyl-7-0-tigloylvilasinin (3) and 12-acetoxy-3-O-acetyl-7-0-methacryloylvilasinin (4), along with five known ones, were isolated from seeds of Azadirachta indica A. Juss. Their structures were elucidated by various spectroscopic methods, including UV, IR, MS, NMR, X-ray crystallography, quantum chemical calculation, as well as by comparison of their spectroscopic data with those reported. In the in vitro cytotoxic assay, 2 showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC50 value of 7.68 +/- 1.74 mu mol/L, and 5 inhibited growth of human cervical cancer Hela cell line, melanoma A375 cell line and promyelocytic leukemia HL-60 cell line, with IC50 12.00 +/- 2.08, 17.44 +/- 2.11, and 13.95 +/- 5.74 mu mol/L, respectively. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：639 / 644

页数：6

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