Effect of lead administration on some blood biochemical parameters

The effect of administration of daily oral doses of lead on various blood biochemical parameters i.e. GOT,GPT, alkaline phosphatase, urea and creatinine in male albino rats was investigated. Lead was fed in daily aral doses of 333, and 1000 mu 1/100 gm body weight for three groups of rats (G1,G2 and G3 respectively) from a solution containing 1000 ppm lead for 20 days. The results indicate that the low dose of lead had a slight effect on GOT and GPT activities; While the highest dose gave a significant effect on GOT and GPT activities. Alkaline phosphatase activity was affected significanlly with lead ingestion at the three levels through the experimental period it may have caused hepatic damage Concerning the effect of lead administration on plasma urea and creatinine, the obtained results show that their level decreased by the increase of lead dose which suggests tissue failure or post renal obstruction.