Evolutionary conservation of meiotic DSB proteins: more than just Spo11

被引：64
|
作者：
Cole, Francesca [1 ]
Keeney, Scott [2 ]
Jasin, Maria [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dev Program, New York, NY 10065 USA
[2] Mem Sloan Kettering Canc Ctr, Program Mol Biol, Howard Hughes Med Inst, New York, NY 10065 USA
来源：
GENES & DEVELOPMENT | 2010年 / 24卷 / 12期
基金：
美国国家卫生研究院;
关键词：
Meiosis; recombination; double-strand break; DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION; COMPARATIVE GENOMICS; CHROMOSOME SYNAPSIS; REPAIR; GENE; INITIATION; RESPONSES; CROSSOVER; MEIOSIS;
D O I：
10.1101/gad.1944710
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.
引用
收藏
页码：1201 / 1207
页数：7
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