Evolutionary conservation of meiotic DSB proteins: more than just Spo11

被引：64

作者：

Cole, Francesca ^{[1
]}

Keeney, Scott ^{[2
]}

Jasin, Maria ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dev Program, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Program Mol Biol, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Meiosis; recombination; double-strand break; DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION; COMPARATIVE GENOMICS; CHROMOSOME SYNAPSIS; REPAIR; GENE; INITIATION; RESPONSES; CROSSOVER; MEIOSIS;

D O I：

10.1101/gad.1944710

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.

引用

页码：1201 / 1207

页数：7

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