Treatment with anti-Sclerostin antibody to stimulate mandibular bone formation
被引:14
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作者:
Tamplen, Matthew
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机构:
Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USAUniv Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USA
Tamplen, Matthew
[1
]
Fowler, Tristan
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机构:
Univ Calif San Francisco, Dept Orthoped Surg, San Francisco, CA 94104 USAUniv Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USA
Fowler, Tristan
[2
]
Markey, Jeffery
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机构:
Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USAUniv Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USA
Markey, Jeffery
[1
]
Knott, P. Daniel
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机构:
Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USAUniv Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USA
Knott, P. Daniel
[1
]
Suva, Larry J.
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机构:
Texas A&M Univ, Dept Vet Physiol, College Stn, TX USAUniv Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USA
Suva, Larry J.
[3
]
Alliston, Tamara
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机构:
Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USA
Univ Calif San Francisco, Dept Orthoped Surg, San Francisco, CA 94104 USAUniv Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USA
Alliston, Tamara
[1
,2
]
机构:
[1] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94104 USA
[2] Univ Calif San Francisco, Dept Orthoped Surg, San Francisco, CA 94104 USA
[3] Texas A&M Univ, Dept Vet Physiol, College Stn, TX USA
来源:
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
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2018年
/
40卷
/
07期
基金:
美国国家卫生研究院;
关键词:
head and neck reconstruction;
mandible;
micro-CT;
osteoradionecrosis;
sclerostin;
DOWN-SYNDROME;
RAT MODEL;
POSTMENOPAUSAL WOMEN;
MINERAL DENSITY;
GENE;
OSTEORADIONECROSIS;
OSTEONECROSIS;
OSTEOPOROSIS;
MASS;
PERIODONTITIS;
D O I:
10.1002/hed.25128
中图分类号:
R76 [耳鼻咽喉科学];
学科分类号:
100213 ;
摘要:
Background: Anti-Sclerostin antibody (Scl-Ab) is a promising new bone anabolic therapy. Although anti-Scl-Ab stimulates bone formation and repair in the appendicular and axial skeleton, its efficacy in the craniofacial skeleton is still poorly understood. Methods: Using an established model of Down syndrome-dependent bone deficiency, 10 Ts65Dn mice and 10 wild-type mice were treated weekly via i.v. tail vein injection with vehicle or anti-Sclerostin for 3 weeks and euthanized 1 week after. Results: Wild-type mice treated with the anti-Scl-Ab had increased mandibular bone, trabecular thickness, and alveolar height compared with controls. Anti-Scl-Ab increased Ts65Dn mandibular bone parameters such that they were statistically indistinguishable from those in vehicle-treated wild-type mandibles. Conclusion: Treatment with anti-Scl-Ab significantly increased mandibular bone mass and alveolar height in wild type mice and normalized mandibular bone mass and alveolar height in Ts65Dn mice. The anti-Scl-Ab therapy represents a novel method for increasing mandibular bone formation.
机构:
Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA
Nanjing Med Univ, Dept Anat Histol & Embryol, Nanjing, Jiangsu, Peoples R ChinaWashington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA
Sun, Weiwei
Shi, Yu
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机构:
Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA
Shi, Yu
Lee, Wen-Chih
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h-index: 0
机构:
Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA
Lee, Wen-Chih
Lee, Seung-Yon
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA
Lee, Seung-Yon
Long, Fanxin
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63110 USA
机构:
Univ Med Ctr Hamburg Eppendorf, Dept Trauma & Orthoped Surg, Mol Skeletal Biol Lab, D-20246 Hamburg, GermanyTech Univ Dresden, Dept Med 3, Med Ctr, Div Endocrinol, D-01307 Dresden, Germany
Taipaleenmaeki, Hanna
Tsourdi, Elena
论文数: 0引用数: 0
h-index: 0
机构:
Tech Univ Dresden, Dept Med 3, Med Ctr, Div Endocrinol, D-01307 Dresden, Germany
Tech Univ Dresden, Dept Med 3, Med Ctr, Div Mol Bone Biol, D-01307 Dresden, GermanyTech Univ Dresden, Dept Med 3, Med Ctr, Div Endocrinol, D-01307 Dresden, Germany
Tsourdi, Elena
Winter, Elizabeth M.
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h-index: 0
机构:
Leiden Univ, Med Ctr, Dept Med, Ctr Bone Qual,Div Endocrinol, NL-2300 RC Leiden, NetherlandsTech Univ Dresden, Dept Med 3, Med Ctr, Div Endocrinol, D-01307 Dresden, Germany
机构:
Nagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, JapanNagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, Japan
Ozawa, Yuto
Takegami, Yasuhiko
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机构:
Nagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, JapanNagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, Japan
Takegami, Yasuhiko
Osawa, Yusuke
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h-index: 0
机构:
Nagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, JapanNagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, Japan
Osawa, Yusuke
Asamoto, Takamune
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h-index: 0
机构:
Nagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, JapanNagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, Japan
Asamoto, Takamune
Tanaka, Shinya
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机构:
Nagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, JapanNagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, Japan
Tanaka, Shinya
Imagama, Shiro
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机构:
Nagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, JapanNagoya Univ, Dept Orthopaed Surg, Grad Sch Med, 65 Tsurumai cho,8 Showa ku, Nagoya, Japan