Sequential decarboxylative azide-alkyne cycloaddition and dehydrogenative coupling reactions: one-pot synthesis of polycyclic fused triazoles

被引：7

作者：

Bharathimohan, Kuppusamy ^{[1
,2
]}

Ponpandian, Thanasekaran ^{[3
]}

Ahamed, A. Jafar ^{[1
]}

Bhuvanesh, Nattamai ^{[4
]}

机构：

[1] Bharathidasan Univ, Jamal Mohamed Coll, PG & Res Dept Chem, Thiruchirapalli 620020, Tamil Nadu, India

[2] Orchid Chem & Pharmaceut Ltd, R&D Ctr, Drug Discovery Res, Madras 600119, Tamil Nadu, India

[3] Inogent Labs Pvt Ltd, API R&D, IDA, Hyderabad 500076, Andhra Pradesh, India

[4] Texas A&M Univ, Dept Chem, Xray Diffract Lab, College Stn, TX 77842 USA

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷

关键词：

copper(II) acetate; decarboxylative CuAAC; dehydrogenative coupling; fused triazoles; one-pot synthesis; H BOND FUNCTIONALIZATION; DIRECT ARYLATIONS; PALLADIUM; 1,2,3-TRIAZOLES; ACID; ACTIVATION; THIAZOLES; MECHANISM; INDOLES;

D O I：

10.3762/bjoc.10.321

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe a one-pot protocol for the synthesis of a novel series of polycyclic triazole derivatives. Transition metal-catalyzed decarboxylative CuAAC and dehydrogenative cross coupling reactions are combined in a single flask and achieved good yields of the respective triazoles (up to 97% yield). This methodology is more convenient to produce the complex polycyclic molecules in a simple way.

引用

页码：3031 / 3037

页数：7

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