Assembly of the 30S ribosomal subunit

被引：100
|
作者：
Culver, GM [1 ]
机构：
[1] Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA
来源：
BIOPOLYMERS | 2003年 / 68卷 / 02期
关键词：
ribosomes; assembly; 30S subunit; in vitro reconstitution;
D O I：
10.1002/bip.10221
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ribosomes are large macromolecular complexes responsible for cellular protein synthesis. The smallest known cytoplasmic ribosome is found in prokaryotic cells; these ribosomes are about 2.5 MDa and contain more than 4000 nucleotides of RNA and greater than 50 proteins. These components are distributed into two asymmetric subunits. Recent advances in structural studies of ribosomes and ribosomal subunits have revealed intimate details of the interactions within fully assembled particles. In contrast, many details of how these massive ribonucleoprotein complexes assemble remain elusive. The goal of this review is to discuss some crucial aspects of 30S ribosomal subunit assembly. (C) 2003 Wiley Periodicals, Inc.
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页码：234 / 249
页数：16
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