Granulocyte-macrophage colony-stimulating factor in post-remission therapy of acute myeloid leukemia

被引：0

作者：

Sousa, AB ^{[1
]}

Fernandes, JP ^{[1
]}

Costa, I ^{[1
]}

Ferreira, G ^{[1
]}

Nunes, O ^{[1
]}

Ribeiro, P ^{[1
]}

Neves, A ^{[1
]}

Cruz, E ^{[1
]}

Aveiro, F ^{[1
]}

Rodrigues, AS ^{[1
]}

Bernardo, M ^{[1
]}

Conduto, A ^{[1
]}

Goncalves, AJ ^{[1
]}

Monteiro, A ^{[1
]}

Sousa, M ^{[1
]}

Soares, VH ^{[1
]}

Veiga, J ^{[1
]}

Gouveia, J ^{[1
]}

机构：

[1] Hosp Capuchos, Hematol Serv, P-1150 Lisboa, Portugal

来源：

HEMATOLOGY AND CELL THERAPY | 1998年 / 40卷 / 02期

关键词：

GM-CSF; priming; acute myeloid leukemia; post-remission therapy;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The impact on occult leukemia of GM-CSF as a sensitizing agent has not been studied. We treated 41 adult patients with de novo acute myeloid leukemia, 25 of whom achieved complete remission and were given 1 to 3 post-remission courses, each course including GM-CSF begun 4 days prior to chemotherapy and given until day 3. After a median follow-up of 32 months, the probability of remaining in continuous complete remission was 17% at 46 months. GM-CSF in this setting was not associated with an improved outcome, arguing against a priming effect.

引用

页码：63 / 66

页数：4

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