Discovery and structure-activity relationship of pyrrolo[2,1-f][1,2,4]triazines as inhibitors of phosphatidylinositol 3-kinase δ (PI3Kδ) for the treatment of immunological disorders

被引：0

作者：

Shi, Qing ^{[1
]}

Marcoux, David ^{[1
]}

Liu, Qingjie ^{[1
]}

Batt, Douglas ^{[1
]}

Cornelius, Lyndon ^{[1
]}

Srivastava, Anurag ^{[1
]}

Cherney, Robert ^{[1
]}

Qin, Lan-ying ^{[1
]}

Ruan, Zheming ^{[1
]}

Neels, James ^{[1
]}

Bhide, Rajeev ^{[1
]}

Li, Ling ^{[1
]}

Bertrand, Myra Beaudoin ^{[1
]}

Gong, Hua ^{[1
]}

Watterson, Scott ^{[1
]}

Pan, Jie ^{[1
]}

Tang, Huaping ^{[1
]}

Fan, Jingsong ^{[1
]}

Yarde, Melissa ^{[1
]}

Cvijic, Mary Ellen ^{[1
]}

Obermeier, Mary ^{[1
]}

Fura, Aberra ^{[1
]}

Weigelt, Carolyn ^{[1
]}

Galella, Michael ^{[1
]}

Sack, Jack ^{[1
]}

Muckelbauer, Jodi ^{[1
]}

Gillooly, Kathleen ^{[1
]}

McIntyre, Kim ^{[1
]}

Ruan, Qian ^{[1
]}

Poss, Michael ^{[1
]}

Hynes, John ^{[1
]}

Macor, John ^{[1
]}

Carter, Percy ^{[1
]}

Ruepp, Stefan ^{[1
]}

Schieven, Gary ^{[1
]}

Tino, Joseph ^{[1
]}

机构：

[1] Bristol Myers Squibb, Princeton, NJ USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 255卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页数：1

共 50 条

[31] Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure-Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives
Nishimura, Nobuko
Siegmund, Aaron
Liu, Longbin
Yang, Kevin
Bryan, Marian C.
Andrews, Kristin L.
Bo, Yunxin
Booker, Shon K.
Caenepeel, Sean
Freeman, Daniel
Liao, Hongyu
McCarter, John
Mullady, Erin L.
San Miguel, Tisha
Subramanian, Raju
Tamayo, Nuria
Wang, Ling
Whittington, Douglas A.
Zalameda, Leeanne
Zhang, Nancy
Hughes, Paul E.
Norman, Mark H.
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (13) : 4735 - 4751
[32] Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections
McPhail, Jacob A.
Burke, John E.
DRUGGABLE LIPID SIGNALING PATHWAYS, 2020, 1274 : 203 - 222
[33] Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors
Wang, Lan
Stanley, Mark
Boggs, Jason W.
Crawford, Terry D.
Bravo, Brandon J.
Giannetti, Anthony M.
Harris, Seth F.
Magnuson, Steven R.
Nonomiya, Jim
Schmidt, Stephen
Wu, Ping
Ye, Weilan
Gould, Stephen E.
Murray, Lesley J.
Ndubaku, Chudi O.
Chen, Huifen
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (18) : 4546 - 4552
[34] Privileged Scaffolds or Promiscuous Binders: A Glance of Pyrrolo[2,1-f][1,2,4]triazines and Related Bridgehead Nitrogen Heterocycles in Medicinal Chemistry
Song, Yu'ning
Zhan, Peng
Zhang, Qingzhu
Liu, Xinyong
CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (08) : 1528 - 1548
[35] Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors
Xin, Minhang
Zhang, Liandi
Tang, Feng
Tu, Chongxing
Wen, Jun
Zhao, Xinge
Liu, Zhaoyu
Cheng, Lingfei
Shen, Han
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (04) : 1429 - 1440
[36] Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K)
Van Dort, Martian E.
Hong, Hao
Wang, Hanxiao
Nino, Charles A.
Lombardi, Rachel L.
Blanks, Avery E.
Galban, Stefanie
Ross, Brian D.
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (06) : 2512 - 2522
[37] Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine derivatives as c-Met kinase inhibitors
Caballero, Julio
Quiliano, Miguel
Alzate-Morales, Jans H.
Zimic, Mirko
Deharo, Eric
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2011, 25 (04) : 349 - 369
[38] Discovery of pyrrolo[2,1-f][1,2,4]triazine C5-ketones as potent, orally active inhibitors of tropomyosin-related kinases
Fink, Brian E.
Kim, Soong-Hoon
Zhao, Yufen
Wittman, Mark
Tokarski, John
Obermeier, Mary
Gottardis, Marco
McDevitt, Theresa
You, Dan
Lorenzi, Matthew
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
[39] Pyrrolo[2,1-f][1,2,4] triazines: From C-nucleosides to kinases and back again, the remarkable journey of a versatile nitrogen heterocycle
Ott, Gregory R.
Favor, David A.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (18) : 4238 - 4246
[40] Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal
Yang, Pai-Hao
Cheung, William K. C.
Peng, Ying
He, Ming-Liang
Wu, Guo-Qing
Xie, Dan
Jiang, Bing-Hua
Huang, Qiu-Hua
Chen, Zhu
Lin, Marie C. M.
Kung, Hsiang-Fu
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (13) : 8486 - 8495

← 1 2 3 4 5 →