Concise Synthesis of Vesnarinone and Its Analogues by Using Pd-Catalyzed C-N Bond-Forming Reactions

被引：6

作者：

See, Yi Yang ^{[1
,2
]}

Tuan Thanh Dang ^{[1
]}

Chen, Anqi ^{[1
]}

Seayad, Abdul Majeed ^{[1
]}

机构：

[1] Inst Chem & Engn Sci, Singapore 138665, Singapore

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 33期

关键词：

Total synthesis; Homogeneous catalysis; Heterogeneous catalysis; Cross-coupling; Amination; Palladium; CROSS-COUPLING REACTIONS; TEMPERATURE SUZUKI-MIYAURA; BUCHWALD-HARTWIG; ARYL HALIDES; PALLADIUM NANOPARTICLES; CARBONYLATION REACTIONS; ATMOSPHERIC-PRESSURE; CYTOKINE PRODUCTION; AMINOCARBONYLATION; EFFICIENT;

D O I：

10.1002/ejoc.201403054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and concise synthesis of vesnarinone and its analogues from readily available starting materials and by using catalytic C-N bond-forming reactions is reported. In this protocol, a homogeneous Pd-catalyzed Buchwald-Hartwig amination and a supported Pd nanoparticles catalyzed aminocarbonylation were utilized as the two key reactions to prepare vesnarinone in an overall yield of 73%. Sixteen analogues were also synthesized in up to 89% overall yield.

引用

页码：7405 / 7412

页数：8

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