Baseline associations between biomarkers, cognitive function, and self-regulation indices in the Cognitive and Self-regulatory Mechanisms of Obesity Study

被引:4
|
作者
Hawkins, Misty A. W. [1 ]
Keirns, Natalie G. [1 ]
Baraldi, Amanda N. [1 ]
Layman, Harley M. [1 ]
Stout, Madison E. [1 ]
Smith, Caitlin E. [1 ,2 ]
Gunstad, John [3 ]
Hildebrand, Deana A. [4 ]
Vohs, Kathleen D. [5 ]
Lovallo, William R. [6 ,7 ]
机构
[1] Oklahoma State Univ, Dept Psychol, 116 Psychol Bldg, Stillwater, OK 74078 USA
[2] Med Univ South Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA
[3] Kent State Univ, Dept Psychol Sci, Kent, OH 44242 USA
[4] Oklahoma State Univ, Dept Nutr Sci, Stillwater, OK 74078 USA
[5] Univ Minnesota, Carlson Sch Management, Minneapolis, MN USA
[6] Oklahoma City VA Med Ctr, Oklahoma City, OK USA
[7] Univ Oklahoma, Hlth Sci Ctr, Dept Psychiat & Behav Sci, Oklahoma City, OK 73190 USA
来源
OBESITY SCIENCE & PRACTICE | 2021年 / 7卷 / 06期
关键词
biomarkers; cardiometabolic; cognition; glucose; self-regulation; BODY-MASS INDEX; INSULIN-RESISTANCE; WEIGHT-LOSS; WAIST CIRCUMFERENCE; METABOLIC SYNDROME; BUILT ENVIRONMENT; PHYSICAL-ACTIVITY; HEALTH; RISK; PREDICTORS;
D O I
10.1002/osp4.537
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Understanding how biological, cognitive, and self-regulatory factors are related to obesity, and weight regulation is clearly needed to optimize obesity prevention and treatment. The objective of this investigation was to understand how baseline biological, cognitive, and self-regulatory factors are related to adiposity at the initiation of a behavioral weight loss intervention among treatment-seeking adults with overweight/obesity. Methods: Participants (N = 107) in the Cognitive and Self-regulatory Mechanisms of Obesity Study (Identifier-NCT02786238) completed a baseline assessment with anthropometric, cardiometabolic, inflammatory, cognitive function, and self-regulation measures as part of a larger on-going trial. Data were analyzed with linear regression. Results: At baseline, body mass index, body fat percentage, and waist circumference (WC) were positively associated with fasting insulin and insulin resistance. Higher WC was related to higher fasting glucose and hemoglobin A1c (HbA1c). Higher glucose and insulin resistance levels were related to lower list sorting working memory. Higher glucose and HbA1c levels were negatively associated with reading scores. Cognitive function and self-regulation indices were unrelated. Conclusions: In adults with overweight/obesity entering a weight loss treatment study: (1) elevated WC and associated glycemic impairment were negatively associated with cognition, (2) poorer executive function and reading abilities were associated with poorer glycemic control, and (3) objectively measured cognitive functions were unrelated to self-reported/behavioral measures of self-regulation. Such findings increase understanding of the relationships between adiposity, biomarkers, cognition, and self-regulation at treatment initiation and may ultimately inform barriers to successful obesity treatment response.
引用
收藏
页码:669 / 681
页数:13
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