Diagnosis of latent tuberculosis by ELISPOT assay and tuberculin skin test

被引：5
|
作者：
Du, F. [1 ]
Zhang, Z. [1 ,2 ]
Gao, T. [2 ]
Liu, Z. [1 ]
Jia, H. [1 ]
Xing, A. [1 ]
Du, B. [1 ]
Sun, Q. [1 ]
Cao, T. [1 ]
Zhang, Z. [1 ,2 ]
机构：
[1] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Beijing Key Lab Drug Resistant TB Res, Beijing 101149, Peoples R China
[2] Changping TB Prevent & Control Inst Beijing, Beijing 102206, Peoples R China
来源：
MEDECINE ET MALADIES INFECTIEUSES | 2016年 / 46卷 / 03期
关键词：
Latent tuberculosis; Interferon-gamma; Tuberculin skin test; PULMONARY TUBERCULOSIS; INFECTION; CHINA; ANTIGENS; STUDENTS; COUNTRY; SCHOOL;
D O I：
10.1016/j.medmal.2016.02.011
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objective. To determine the prevalence of latent tuberculosis infection (LTBI) in college students. Patients and methods. Four hundred and twenty newly admitted college students were enrolled. The Enzyme-Linked ImmunoSpot assay (ELISPOT) was used. Overall, 171 students with ELISPOT assay+/TST+ were monitored for three years to detect active TB disease. Results. The overall positive rate of ELISPOT assay was 40.7% among TST+ students. The ELISPOT positive rates were 36.9%, 45.4%, and 64.3% in groups of TST induration of 10-14 mm, 15-20 mm, and >= 20 mm, respectively, with a significant difference (chi(2) = 10.136, P<0.01) but no significant difference between BCG scar and no scar (41.2% vs. 38.8%; P>0.05). None of the 171 untreated students contracted active TB within the three-year monitoring period. Conclusion. The LTBI rate might be overestimated by TST compared with interferon-gamma release assays. On the basis of a close monitoring, few students developed active TB despite a positive result to the TST and ELISPOT assay. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：150 / 153
页数：4
相关论文
共 50 条
  • [41] Interferon-γ release assays or tuberculin skin test for latent tuberculosis infection?
    Mayanja-Kizza, Harriet
    Katamba, Achilles
    LANCET INFECTIOUS DISEASES, 2020, 20 (12): : 1359 - 1360
  • [42] USE OF THE TUBERCULIN SKIN TEST TO SCREEN HEALTHCARE WORKERS FOR LATENT TUBERCULOSIS INFECTION
    Plumb, I. D.
    Miller, P.
    Tamne, S.
    Creer, D.
    THORAX, 2008, 63 : A112 - A112
  • [43] The reliability of tuberculin skin test in the diagnosis of latent tuberculosis infection in psoriasis patients: A case-control study
    Surucuoglu, Suheyla
    Turel Ermertcan, Aylin
    Cetinarslan, Tubanur
    Ozkutuk, Nuri
    DERMATOLOGIC THERAPY, 2020, 33 (04)
  • [44] The diagnosis of latent tuberculosis infection in children in XXI century. Is tuberculin skin test still up to date?
    Bielecka, Teresa
    Komorowska-Piotrowska, Anna
    Mazur, Agnieszka
    Feleszko, Wojciech
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2015, 69 : 1130 - 1139
  • [45] O1: Tuberculin skin test versus blood immunologic diagnosis of latent Mycobacterium tuberculosis infection
    Jamai, A.
    Schepers, K.
    Verscheure, V.
    Hougardy, J. -M.
    De Breucker, S.
    Mascart, F.
    Pepersack, T.
    ACTA CLINICA BELGICA, 2007, 62 (06): : 467 - 467
  • [46] Superiority of Interferon Gamma Assay Over Tuberculin Skin Test for Latent Tuberculosis in Inflammatory Bowel Disease Patients in Brazil
    Renata F. Amorim
    Eduardo R. C. Viegas
    Antonio José V. Carneiro
    Barbara C. Esberard
    Evelyn S. Chinem
    Raquel S. Correa
    Luciana Rodrigues
    Marcelo Ribeiro-Alves
    Kelly S. Silva
    Heitor S. de Souza
    Ana Teresa P. Carvalho
    Digestive Diseases and Sciences, 2019, 64 : 1916 - 1922
  • [47] Comparison Of Tuberculin Skin Test With Interferon Gamma Release Assay (quantiferon®) For Detection Of Latent Tuberculosis Infection In Cancer Patients
    Galindo Pedraza, J. L.
    Callejas Gutierrez, A. M.
    Suarez Zamora, D. A.
    Baldion Elorza, A. M.
    Palacios Ortiz, D. M.
    Hanabergh, C.
    Caicedo Verastegui, M. P.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
  • [48] Superiority of Interferon Gamma Assay Over Tuberculin Skin Test for Latent Tuberculosis in Inflammatory Bowel Disease Patients in Brazil
    Amorim, Renata F.
    Viegas, Eduardo R. C.
    Carneiro, Antonio Jose V.
    Esberard, Barbara C.
    Chinem, Evelyn S.
    Correa, Raquel S.
    Rodrigues, Luciana
    Ribeiro-Alves, Marcelo
    Silva, Kelly S.
    de Souza, Heitor S.
    Carvalho, Ana Teresa P.
    DIGESTIVE DISEASES AND SCIENCES, 2019, 64 (07) : 1916 - 1922
  • [49] COMPARISON OF INTERFERON-GAMMA RELEASE ASSAY VERSUS TUBERCULIN SKIN TEST FOR LATENT TUBERCULOSIS SCREENING IN HEMODIALYSIS PATIENTS
    Ates, G.
    Ozekinci, T.
    Yildiz, T.
    Danis, R.
    BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2009, 23 (02) : 1242 - 1246
  • [50] Comparison of an interferon-gamma release assay and the tuberculin skin test for diagnosis of latent tuberculosis in homeless people in Iran: a cross-sectional study
    Amiri, Fahimeh Bagheri
    Saifi, Mahnaz
    Gouya, Mohammad Mehdi
    Rohani, Mahdi
    Mostafavi, Ehasn
    INFECTIOUS DISEASES, 2015, 47 (08) : 536 - 541
12345