The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis

被引：11

作者：

Skorupska, Anna ^{[1
]}

Lenda, Rafal ^{[1
]}

Ozyhar, Andrzej ^{[1
]}

Bystranowska, Dominika ^{[1
]}

机构：

[1] Wroclaw Univ Sci & Technol, Dept Biochem Mol Biol & Biotechnol, Fac Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 11期

关键词：

Nucb2; nesfatin-1; carcinogenesis; apoptosis; biomarker; tumors; ANOREXIA-CACHEXIA SYNDROME; PROTEIN-COUPLED RECEPTORS; GROWTH SUPPRESSOR NECDIN; CELL-PROLIFERATION; ESTROGEN-RECEPTOR; PROSTATE-CANCER; TUMOR-GROWTH; NESFATIN-1; EXPRESSION; NUCB2;

D O I：

10.3390/ijms22115687

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin-1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin-1 in tumorigenesis seems to be dual-both pro-metastatic and anti-metastatic. The implication of Nucb2/nesfatin-1 in carcinogenesis seems to be tissue dependent. Herein, we review the role of Nucb2/nesfatin-1 in both carcinogenesis and the apoptosis process, and we also highlight the multifaceted nature of Nucb2/nesfatin-1.

引用

页数：15

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