The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis

被引：11
|
作者：
Skorupska, Anna [1 ]
Lenda, Rafal [1 ]
Ozyhar, Andrzej [1 ]
Bystranowska, Dominika [1 ]
机构：
[1] Wroclaw Univ Sci & Technol, Dept Biochem Mol Biol & Biotechnol, Fac Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 11期
关键词：
Nucb2; nesfatin-1; carcinogenesis; apoptosis; biomarker; tumors; ANOREXIA-CACHEXIA SYNDROME; PROTEIN-COUPLED RECEPTORS; GROWTH SUPPRESSOR NECDIN; CELL-PROLIFERATION; ESTROGEN-RECEPTOR; PROSTATE-CANCER; TUMOR-GROWTH; NESFATIN-1; EXPRESSION; NUCB2;
D O I：
10.3390/ijms22115687
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin-1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin-1 in tumorigenesis seems to be dual-both pro-metastatic and anti-metastatic. The implication of Nucb2/nesfatin-1 in carcinogenesis seems to be tissue dependent. Herein, we review the role of Nucb2/nesfatin-1 in both carcinogenesis and the apoptosis process, and we also highlight the multifaceted nature of Nucb2/nesfatin-1.
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页数：15
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