Facile diastereoselective reactions of chiral 1,3-oxazolidines with Grignard reagents; Asymmetric syntheses of 2-substituted and 2,6-disubstituted piperidines

被引：0

作者：

Poerwono, H ^{[1
]}

Higashiyama, K ^{[1
]}

Yamauchi, T ^{[1
]}

Takahashi, H ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 142, Japan

来源：

HETEROCYCLES | 1997年 / 46卷

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(S)- and (R)-2-Phenylpiperidines, (S)- and (R)-2-methylpiperidines, meso- and (2R, 6R)-2,6-diphenylpiperidines, and meso- and (2S, 6S)-2,6-dimethylpiperidines were synthesized asymmetrically starting from the diastereoselective addition of Grignard reagents to chiral 1,3-oxazolidines, converting of 1-aza-4-oxabicyclo[4.3.0]nonane derivatives as pivotal intermediates.

引用

页码：385 / 400

页数：16

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