An efficient route to 3-substituted cyclobutanone derivatives

被引：8
|
作者：
Kabalka, GW [1 ]
Yao, ML
机构：
[1] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA
[2] Univ Tennessee, Dept Radiol, Knoxville, TN 37996 USA
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 09期
关键词：
D O I：
10.1016/S0040-4039(03)00081-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient route to 3-(hydroxymethyl)cyclobutanone acetals via a [2 + 2] cycloaddition reaction is reported. The dramatic effect of different diol acetals on benzyl deprotection is discussed. Efficient synthesis of two synthetically useful intermediates, 3-methylenecyclobutanone acetal and 3-(bromomethyl)cyclobutanone, are provided. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1879 / 1881
页数：3
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