Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury

被引：88

作者：

Satake, K

Matsuyama, Y

Kamiya, M

Kawakami, H

Iwata, H

Adachi, K

Kiuchi, K ^{[1
]}

机构：

[1] Nagoya Univ, Sch Med, Dept Orthopaed Surg, Nagoya, Aichi 4668550, Japan

[2] RIKEN, Biomimet Control Res Program, Lab Genes Motor Syst, Moriyama Ku, Nagoya, Aichi 4630003, Japan

[3] Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 17期

关键词：

glial cell line-derived neurotrophic factor; macrophage; microglia; rat; spinal cord injury; weight drop technique;

D O I：

10.1097/00001756-200011270-00054

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the temporal and spatial expression patterns of the GDNF gene after subjecting rats to an acute contusion injury of the spinal cord using the weight drop technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that GDNF transcription in the spinal cord began to increase within 30 min after injury and peaked within 3 h. Immunohistochemical analysis showed GDNF immunoreactivity to be present mainly in microglia and macrophages 1 day after injury,but not in neurons or astrocytes. This immediate upregulation of GDNF gene expression may be a component of an inflammatory process and probably exerts a protective effect on neurons following spinal cord injury (SCI). NeuroReport 11:3877-3881 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3877 / 3881

页数：5

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