Applying Computational Fluid Dynamics Technology in Bioprocesses

被引：1
|
作者：
Fang, Zhiwu [1 ]
机构：
[1] Syst Qual Design Inc, Newbury Pk, CA USA
来源：
BIOPHARM INTERNATIONAL | 2010年 / 23卷 / 05期
关键词：
LARGE-EDDY SIMULATIONS; DUAL RUSHTON TURBINES; CELL BUBBLE INTERACTIONS; STIRRED VESSEL; MACRO-INSTABILITIES; TRAILING VORTICES; CFD SIMULATIONS; MIXING TIME; MICROSCOPIC VISUALIZATION; PARTICLE DISTRIBUTION;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Computational fluid dynamics (CFD) has been widely applied as a trouble-shooting and Quality by Design (QbD) tool for bioprocess from downstream, to upstream, to fill finish. Part 1 of this article series provided an overview of the technology, and the model setup. Here in part 2, we provide a detailed review of the applications of CFD in cell culture and fermentation processes, including flow characterization, mixing, resuspension, scale-up, and cell damage.
引用
收藏
页码：42 / +
页数：10
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