Chemical Constituents of the Aerial Part of Valeriana officinalis var. latifolia Miq. With COX-2 Inhibitory Activity

被引：3

作者：

Ming, Weikang ^{[1
,2
,3
]}

Zhang, Zizhen ^{[1
,3
]}

Li, Yanan ^{[1
,3
]}

Yi, Ping ^{[1
,3
]}

Wang, Miaomiao ^{[1
,3
]}

An, Zhengbin ^{[1
,3
]}

Li, Fei ^{[1
,3
]}

Gu, Wei ^{[1
,2
,3
]}

Hao, Xiaojiang ^{[1
,2
,3
,4
]}

Yuan, Chunmao ^{[1
,2
,3
]}

机构：

[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China

[2] Guizhou Med Univ, Sch Pharmacuet Sci, Guiyang, Peoples R China

[3] Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China

[4] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2022年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Valeriana officinalis var; latifolia Miq; valerianaceae; iridoids; lignans; COX-2; inhibitors; LIGNANS; ROOTS;

D O I：

10.1177/1934578X221078628

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twelve compounds, including a new iridoid (1) and 11 known compounds, were obtained from the aerial part of Valeriana officinalis var. latifolia Miq. Their structures were assigned by spectroscopic and mass spectrometric methods. All isolates were screened in vitro for cyclooxygenase-2 (COX-2) inhibitory activity. Two compounds (9 and 10) exhibited significant COX-2 inhibitory activity, with IC50 values ranging from 0.67 to 6.77 mu M. The possible recognition mechanism between compound 9 and COX-2 was predicted by molecular docking analysis.

引用

页数：6

共 19 条

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