Simple and efficient synthesis of 2-[18F]fluoroethyl triflate for high yield 18fluoroethylation

被引：4

作者：

Peters, Tanja ^{[1
]}

Vogg, Andreas ^{[1
]}

Oppel, Iris M. ^{[2
]}

Schmaljohann, Joern ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Dept Nucl Med, D-52074 Aachen, Germany

[2] Rhein Westfal TH Aachen, Dept Inorgan Chem, D-52074 Aachen, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 2014年 / 94卷

关键词：

2-[F-18]fluoroethyl triflate; 2-[F-18]fluoroethanol; F-18-fluoroethylation; Fluorine-18; BIODISTRIBUTION;

D O I：

10.1016/j.apradiso.2014.07.016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The [F-18]fluoroethyl moiety has been widely utilized in the synthesis of F-18-labelled compounds. The aim of this work was the reliable synthesis of [F-18]FEtOTf with a novel strategy to increase the reactivity of the commonly used [F-18]FEB and [F-18]FEtOTos. [F-18]FEtOTf and the intermediate [F-18]FEtOH were synthesized in high RCY (78% and 85%, respectively) and purified by SPE. The high potency of [F-18] FEtOTf was shown by the efficient alkylation of the deactivated nucleophile aniline under mild conditions, as well as by the synthesis of [F-18]FEC. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：141 / 146

页数：6

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