Design of a molecular clock with RNA-mediated regulation

被引：0

作者：

Blanchini, Franco ^{[1
]}

Samaniego, Christian Cuba ^{[2
]}

Franco, Elisa ^{[2
]}

Giordano, Giulia ^{[1
]}

机构：

[1] Univ Udine, Dept Math & Comp Sci, I-33100 Udine, Italy

[2] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92502 USA

来源：

2014 IEEE 53RD ANNUAL CONFERENCE ON DECISION AND CONTROL (CDC) | 2014年

关键词：

APTAMERS; DNA;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.

引用

页码：4611 / 4616

页数：6

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