Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation

被引：35
|
作者：
Hauss-Wegrzyniak, B
Galons, JP
Wenk, GL
机构：
[1] Univ Arizona, Arizona Res Labs, Div Neural Syst Memory & Aging, Tucson, AZ 85724 USA
[2] Univ Arizona, Lab Radiol, Tucson, AZ 85724 USA
来源：
EXPERIMENTAL NEUROLOGY | 2000年 / 165卷 / 02期
关键词：
brain inflammation; hippocampus; magnetic resonance imaging; rats; Alzheimer's disease;
D O I：
10.1006/exnr.2000.7469
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.
引用
收藏
页码：347 / 354
页数：8
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