A highly flexible dinuclear ruthenium(II)-platinum(II) complex:: Crystal structure and binding to 9-ethylguanine

被引：80
|
作者：
van der Schilden, K
Garcìa, F
Kooijman, H
Spek, AL
Haasnoot, JG
Reedijk, J
机构：
[1] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands
[2] Univ Utrecht, Bijvoet Ctr Biomol Res, NL-3584 CH Utrecht, Netherlands
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 42期
关键词：
antitumor agents; binuclear complexes; platinum; ruthenium; structure elucidation;
D O I：
10.1002/anie.200460319
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The length and high flexibility of the linker in a heterodinuclear ruthenium-platinum complex (see X-ray crystal structure) enables the platinum unit to independently interact with DNA by π-π stacking or coordination, possibly after pre-association of the 2 + charged ruthenium unit. A prototype of this challenging class of potentially cytostatic compounds is presented.
引用
收藏
页码：5668 / 5670
页数：3
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