Behind the IL-8 ball in prostate cancer

被引：6
|
作者：
Madan, Ravi A. [1 ]
Palena, Claudia [2 ]
机构：
[1] NCI, Genitourinary Malignancies Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
[2] NCI, Tumor Immunol & Biol Lab, Ctr Canc Res, NIH, Bldg 10, Bethesda, MD 20892 USA
来源：
NATURE CANCER | 2021年 / 2卷 / 08期
关键词：
REDUCED CLINICAL BENEFIT; THERAPY; INTERLEUKIN-2;
D O I：
10.1038/s43018-021-00235-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer is largely unresponsive to immunotherapy. A new study finds elevated expression of the chemokine IL-8, or its mouse homolog Cxcl15, in prostate cancer after castration, which leads to the recruitment of immunosuppressive myeloid cells. Blocking tumor infiltration with these cells could improve the response to immune-checkpoint inhibition and androgen-deprivation therapy.
引用
收藏
页码：775 / 776
页数：2
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