Behind the IL-8 ball in prostate cancer

被引：6

作者：

Madan, Ravi A. ^{[1
]}

Palena, Claudia ^{[2
]}

机构：

[1] NCI, Genitourinary Malignancies Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] NCI, Tumor Immunol & Biol Lab, Ctr Canc Res, NIH, Bldg 10, Bethesda, MD 20892 USA

来源：

NATURE CANCER | 2021年 / 2卷 / 08期

关键词：

REDUCED CLINICAL BENEFIT; THERAPY; INTERLEUKIN-2;

D O I：

10.1038/s43018-021-00235-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer is largely unresponsive to immunotherapy. A new study finds elevated expression of the chemokine IL-8, or its mouse homolog Cxcl15, in prostate cancer after castration, which leads to the recruitment of immunosuppressive myeloid cells. Blocking tumor infiltration with these cells could improve the response to immune-checkpoint inhibition and androgen-deprivation therapy.

引用

页码：775 / 776

页数：2

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