ABERRANT SPLICING DURING ERYTHROID DIFFERENTIATION IN SF3B1 MUTATED SIDEROBLASTIC

被引:0
|
作者
Conte, S. [1 ]
Vesterlund, L. [2 ,3 ]
Katayama, S. [2 ,3 ,4 ]
Karimi, M. [1 ]
Unneberg, P. [5 ]
Papaemmanuil, E. [6 ]
Jansson, M. [1 ]
Mortera-Blanco, T. [1 ]
Dimitriou, M. [1 ]
Sander, B. [7 ]
Skoog, T. [2 ,3 ]
Campbells, P. [6 ]
Kere, J. [2 ,3 ]
Hellstrom-Lindberg, E. [1 ]
机构
[1] Ctr Hematol & Regenerat Med HERM, Dept Med, Huddinge, Sweden
[2] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden
[3] Karolinska Inst, Ctr Biosci, Stockholm, Sweden
[4] Sci Life Lab, Stockholm, Sweden
[5] Sci Life Lab, Dept Biochem & Biophys, Stockholm, Sweden
[6] Wellcome Trust Sanger Inst, Canc Genet & Genom, Cambridge, England
[7] Karolinska Univ Hosp, Div Pathol, Dept Lab Med, Stockholm, Sweden
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P168
引用
收藏
页码:73 / 74
页数:2
相关论文
共 50 条
  • [31] Review of clinical and genetic variables of SF3B1 mutated uveal melanoma
    Drabarek, W.
    van Poppelen, N.
    Smit, K. N.
    Verdijk, R. M.
    Naus, N.
    Mensink, H.
    Paridaens, D.
    de Klein, A.
    Kilic, E.
    ACTA OPHTHALMOLOGICA, 2018, 96 : 47 - 48
  • [32] Disruption of Intracellular Metal Homeostasis As a Vulnerability in SF3B1 Mutated AML
    Moison, Celine
    Gracias, Deanne
    Schmitt, Julie
    Girard, Simon
    Fortier, Simon
    Boivin, Isabel
    Spinella, Jean-Francois
    Macrae, Tara
    Ruel, Rejean
    Hebert, Josee
    Marinier, Anne
    Sauvageau, Guy
    BLOOD, 2022, 140 : 10680 - 10681
  • [33] Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells
    Buonamici, Silvia
    Darman, Rachel
    Perino, Samantha
    Agrawal, Anant
    Peng, Shouyong
    Seiler, Michael
    Lim, Kian Huat
    Bhavsar, Erica B.
    Feala, Jacob
    Obeng, Esther A.
    Bailey, Suzanna
    Chan, Betty
    Fekkes, Peter
    Keaney, Gregg F.
    Kumar, Pavan
    Kunii, Kaiko
    Lee, Linda
    Mackenzie, Crystal
    Matijevic, Mark
    Mizui, Yoshiharu
    Myint, Khin
    Park, Eunice
    Pazolli, Ermira
    Thomas, Michael
    Wang, John
    Warmuth, Markus
    Yu, Lihua
    Zhu, Ping
    Furman, Richard R.
    Ebert, Benjamin L.
    Smith, Peter G.
    BLOOD, 2015, 126 (23)
  • [34] Targeting SF3B1 mediated splicing control in chronic lymphocytic leukemia
    Chen, Rong
    Plunkett, William
    Kipps, Thomas J.
    Wu, Catherine J.
    Keating, Michael
    Chen, Yuling
    Rassenti, Laura
    Gruber, Michaela
    Ghia, Emanuela
    Qi, Yuan
    Su, Xiaoping
    Wong, Jessica
    LEUKEMIA & LYMPHOMA, 2017, 58 : 219 - 219
  • [35] SF3B1 Splicing Mutation in the Context of Therapy-Related MDS
    Volpe, Virginia
    Al Ali, Najla
    Padron, Eric
    Sallman, David
    Komrokji, Rami
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2020, 20 : S320 - S320
  • [36] The splicing factor SF3B1 is involved in brown adipocyte thermogenic activation
    Castella, Moises
    Mestres-Arenas, Alberto
    Gavalda-Navarro, Aleix
    Blasco-Roset, Albert
    Quesada-Lopez, Tania
    Romero-Carraminana, Ines
    Giralt, Marta
    Villarroya, Francesc
    Cereijo, Ruben
    BIOCHEMICAL PHARMACOLOGY, 2024, 220
  • [37] MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1
    Velasco, Angela Downie Ruiz
    Parsons, Aimee L.
    Heatley, Matthew C.
    Martin, Athena R. G.
    Smart, Alfredo D.
    Shah, Niraj
    Jopling, Catherine L.
    NUCLEIC ACIDS RESEARCH, 2024, 52 (15) : 9210 - 9229
  • [38] SF3B1 Mutation Causes Aberrant Splicing and Downregulation of PPP2R5A in Chronic Lymphocytic Leukemia
    Han, Qimei
    Deng, Libin
    Pei, Lirong
    Choi, Jeong-Hyeon
    Jin, Victor
    Shi, Huidong
    BLOOD, 2017, 130
  • [39] Knockdown of SF3B1 inhibits cell proliferation, invasion and migration triggering apoptosis in breast cancer via aberrant splicing
    Zhang, Ling
    Zhang, Xiaojuan
    Zhang, Haitao
    Liu, Feng
    Bi, Yanghui
    Zhang, Yanyan
    Cheng, Caixia
    Liu, Jing
    BREAST CANCER, 2020, 27 (03) : 464 - 476
  • [40] Understanding the Role of Mutations in SF3B1 and Splicing in Chronic Lymphocytic Leukemia
    Wu, Catherine J.
    BLOOD, 2012, 120 (21)