Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells

被引：32

作者：

Lee, Mi Kyeong ^{[2
]}

Lee, Ki Yong ^{[1
,3
]}

Jeon, Hee Young ^{[1
,3
]}

Sung, Sang Hyun ^{[1
,3
]}

Kim, Young Choong ^{[1
,3
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea

[3] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2009年 / 24卷 / 06期

关键词：

Euscaphis japonica; antifibrotic activity; triterpenoid; HSC-T6; hepatic stellate cells; pomolic acid; ACID-DERIVATIVES; LIVER FIBROSIS; IN-VITRO; LINE; PROLIFERATION; METABOLISM;

D O I：

10.3109/14756360902829709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferation. Activity-guided fractionation led to the isolation of four triterpenoids, friedeline (1), glut-5-en-ol (2), pomolic acid (3), and methylrotundate (4). Among the triterpenoids isolated, pomolic acid (3) significantly inhibited the proliferation of HSCs at concentrations 10 and 100 mu M.

引用

页码：1276 / 1279

页数：4

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