An enantioselective total synthesis of Sch-725674

被引：23
|
作者：
Ramakrishna, Kota [1 ]
Kaliappan, Krishna P. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 01期
关键词：
PIPERIDINE; STRATEGIES; SCH725674; CORE;
D O I：
10.1039/c4ob02136c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioselective total synthesis of Sch-725674, a unique 14-membered macrolactone, has been accomplished in 13 steps. The step-wise dithiane alkylation served as a strategic step to assemble the upper and lower fragments of the molecule, whereas cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction are used as key steps to complete the total synthesis.
引用
收藏
页码：234 / 240
页数：7
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