Catalytic asymmetric hydrogenation of aromatic ketones in room temperature ionic liquids

被引：47
|
作者：
Ngo, HL [1 ]
Hu, AG [1 ]
Lin, WB [1 ]
机构：
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 04期
基金：
美国国家科学基金会;
关键词：
ionic liquid; hydrogenation; asymmetric catalysis;
D O I：
10.1016/j.tetlet.2004.11.150
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polar bisphosphonic acid-derived Ru(BINAP)(DPEN)Cl-2 precatalysts were synthesized and immobilized in room temperature ionic liquids (RTILs) for asymmetric hydrogenation of aromatic ketones with cc values of up to 98.7%. The performance of the Ru catalysts is highly dependent on the nature of imidazolium ILs. For the imidazolium ILs without acidic protons, both ILs and Ru catalysts were recycled by simple extraction and reused. Such a simple immobilization approach also prevented the leaching of Ru (and Ru catalysts) into the chiral secondary alcohol products, and should prove desirable for the production of pharmaceutical intermediates that are free from metal contaminants. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：595 / 597
页数：3
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