Itraconazole lung concentrations in haematological patients

被引：0
|
作者：
Coronel, B
Levron, JC
Dorez, D
Van Devenne, A
Archimbaud, E
Mercatello, A
机构：
[1] Hop Edouard Herriot, Intens Care Unit, Lyon, France
[2] Direct Rech, Janssen Res Fdn, Val De Reuil, France
[3] Hautepierre Hosp, Strasbourg, France
[4] Hop Edouard Herriot, Dept Hematol, Lyon, France
来源：
MYCOSES | 2000年 / 43卷 / 3-4期
关键词：
itraconazole; antimycotic chemotherapy; pharmacokinetics; lung concentration;
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Itraconazole distribution is largely dependent on its high liposolubility. Intrapulmonary lung concentrations remain unknown in haematological patients. We report itraconazole lung concentrations in such patients treated with itraconazole. Itraconazole and hydroxy-itraconazole were measured by high-performance liquid chromatography in concomitant blood samples and lung post-mortem biopsies (three cases) or lung lobectomy (one case). These itraconazole and metabolite lung concentrations were sufficient to be active on Aspergillus.
引用
收藏
页码：125 / 127
页数：3
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