DURABLE REMISSIONS WITH CONTROL OF CYTOKINE RELEASE SYNDROME (CRS) USING T CELLS EXPRESSING CD19 TARGETED CHIMERIC ANTIGEN RECEPTOR (CAR) CTL019 TO TREAT RELAPSED/REFRACTORY (R/R) ACUTE LYMPHOID LEUKEMIA (ALL)

被引:1
|
作者
Levine, B. L. [1 ,2 ,3 ]
Maude, S. [4 ,5 ,6 ]
Zheng, Z. [1 ,2 ]
Shaw, P. [7 ]
Ambrose, D. [1 ]
Aplenc, R. [5 ,6 ]
Barker, C. [4 ,5 ,6 ]
Barrett, D. [4 ,5 ,6 ]
Brogdon, J. [8 ]
Callahan, C. [5 ,6 ]
Chen, F. [1 ]
Chew, A. [1 ]
Davis, M. M. Suhoski [1 ,2 ]
Fesnak, A. D. [1 ,2 ]
Finklestein, J. [1 ]
Frey, N. [8 ]
Lacey, S. [1 ]
Lamontagne, A. [1 ,2 ]
Lewitt, L. [1 ,2 ]
Loew, A. [8 ]
Marcucci, K. [1 ]
Melenhorst, J. [1 ,2 ]
Motley, L. [5 ,6 ]
Mudambi, M. [5 ,6 ]
Nazimuddin, F. [1 ]
O'Rourke, M. [1 ,2 ]
Porter, D. [3 ]
Rheingold, S. R. [5 ,6 ]
Scholler, J. [1 ]
Tayor, C. [1 ,2 ]
White, C. [5 ,6 ]
Wood, P. [9 ]
Young, R. [1 ]
Teachey, D. T. [4 ,5 ,6 ]
June, C. [1 ,2 ,3 ]
Grupp, S. [3 ,4 ,5 ,6 ]
机构
[1] Univ Penn, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA
[2] Univ Penn, Pathol & Lab Med, Philadelphia, PA 19104 USA
[3] Abramson Canc Ctr, Philadelphia, PA USA
[4] Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA
[5] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA
[6] Childrens Hosp Philadelphia, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA
[7] Univ Penn, Biostat & Epidemiol, Philadelphia, PA 19104 USA
[8] Novartis Inst Biomed Res, Cambridge, MA USA
[9] Novartis Pharmaceut, Cell & Gene Therapies Unit, E Hanover, NJ USA
关键词
D O I
10.1016/j.jcyt.2016.03.039
中图分类号
Q813 [细胞工程];
学科分类号
摘要
25
引用
收藏
页码:S14 / S15
页数:2
相关论文
共 50 条
  • [1] Durable remissions, with control and prediction of cytokine release syndrome (CRS), using T cells expressing a CD19-targeted chimeric antigen receptor (CTL019) to treat relapsed/refractory (r/r) pediatric ALL
    Grupp, S.
    Maude, S.
    Shaw, P. A.
    Aplenc, R.
    Barker, C.
    Barrett, D. M.
    Callahan, C.
    Chen, F.
    Finklestein, J.
    Frey, N.
    Lacey, S. F.
    Levine, B. L.
    Melenhorst, J. J.
    Motley, L.
    Nazimuddin, F.
    Porter, D.
    Rheingold, S. R.
    White, C.
    Wood, P. A.
    Zheng, Z.
    Teachey, D. T.
    June, C.
    BONE MARROW TRANSPLANTATION, 2016, 51 : S321 - S322
  • [2] Durable Remissions in Children with Relapsed/Refractory ALL Treated with T Cells Engineered with a CD19-Targeted Chimeric Antigen Receptor (CTL019)
    Grupp, Stephan A.
    Maude, Shannon L.
    Shaw, Pamela A.
    Aplenc, Richard
    Barrett, David M.
    Callahan, Colleen
    Lacey, Simon F.
    Levine, Bruce L.
    Melenhorst, J. Joseph
    Motley, Laura
    Rheingold, Susan R.
    Teachey, David T.
    Wood, Patricia A.
    Porter, David
    June, Carl H.
    BLOOD, 2015, 126 (23)
  • [3] T Cells Engineered with a Chimeric Antigen Receptor (CAR) Targeting CD19 (CTL019) Have Long Term Persistence and Induce Durable Remissions in Children with Relapsed, Refractory ALL
    Grupp, Stephan A.
    Maude, Shannon L.
    Shaw, Pamela
    Aplenc, Richard
    Barrett, David M.
    Callahan, Colleen
    Chew, Anne
    Lacey, Simon F.
    Levine, Bruce L.
    Melenhorst, J. Joseph
    Motley, Laura
    Rheingold, Susan R.
    Shen, Angela
    Teachey, David T.
    Wood, Patricia A.
    Porter, David L.
    June, Carl H.
    BLOOD, 2014, 124 (21)
  • [4] Sustained Remissions Following Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) in Patients with Relapsed or Refractory CD19+Lymphomas
    Schuster, Stephen J.
    Svoboda, Jakub
    Nasta, Sunita Dwivedy
    Porter, David L.
    Chong, Elise A.
    Landsburg, Daniel J.
    Mato, Anthony R.
    Lacey, Simon F.
    Melenhorst, Jan J.
    Chew, Anne
    Hasskarl, Jens
    Shah, Gaurav D.
    Wasik, Mariusz A.
    Marcucci, Katherine T.
    Zheng, Zhaohui
    Levine, Bruce L.
    June, Carl H.
    BLOOD, 2015, 126 (23)
  • [5] Chimeric Antigen Receptor (CAR)-Modified T Cells (CTL019) Induce Durable CNS Remissions in Children with CNS/Combined Bone Marrow and CNS Relapsed/Refractory CD19+Acute Lymphoblastic Leukemia
    Talekar, Mala
    Hucks, George
    Maude, Shannon
    Kawchak, Nicholas
    Motley, Laura
    Barrett, David
    Lacey, Simon
    Levine, Bruce
    Melenhorst, Jan
    Shaw, Pamela
    Callahan, Colleen
    White, Claire
    Barker, Christine
    Baniewicz, Diane
    Duckworth, Mark
    Aplenc, Richard
    Teachey, David
    June, Carl
    Grupp, Stephan
    Rheingold, Susan
    PEDIATRIC BLOOD & CANCER, 2017, 64 : S2 - S2
  • [6] Cellular Kinetics of Chimeric Antigen Receptor T Cells (CTL019) in Patients with Relapsed/Refractory CD19+Leukemia
    Mueller, Karen Thudium
    Chakraborty, Abhijit
    Wood, Patricia A.
    Awasthi, Rakesh
    Quintas-Cardama, Alfonso
    Han, Xia
    Maude, Shannon L.
    Grupp, Stephan A.
    Porter, David L.
    Frey, Noelle
    Marcucci, Katherine T.
    Levine, Bruce L.
    Melenhorst, Jan J.
    June, Carl H.
    Lacey, Simon F.
    BLOOD, 2016, 128 (22)
  • [7] Cytokine Release Syndrome (CRS) after Chimeric Antigen Receptor (CAR) T Cell Therapy for Relapsed/Refractory (R/R) CLL
    Porter, David L.
    Lacey, Simon F.
    Hwang, Wei-Ting
    Shaw, Pamela
    Frey, Noelle V.
    Chew, Anne
    Chen, Fang
    Kalos, Michael
    Gonzalez, Vanessa
    Marcucci, Katherine T.
    Maude, Shannon L.
    Melenhorst, Jan J.
    Litchman, Manuel
    Teachey, David T.
    Shen, Angela
    Quintas-Cardamas, Alfonso
    Wood, Patricia A.
    Levine, Bruce L.
    June, Carl H.
    Grupp, Stephan A.
    BLOOD, 2014, 124 (21)
  • [8] CD19-TARGETED CHIMERIC ANTIGEN RECEPTOR (CAR)-MODIFIED T (CTL019) CELLS IN PEDIATRIC ALL: IMMUNE ACTIVATION SYNDROMES AND DURABLE RESPONSE
    Barrett, David
    Kalos, Michael
    Teachey, David
    Levine, Bruce
    Rheingold, Susan
    Aplenc, Richard
    Porter, David
    June, Carl
    Grupp, Stephan
    PEDIATRIC BLOOD & CANCER, 2013, 60 : S1 - S1
  • [9] Chimeric Antigen Receptor T Cells Directed Against CD19 Induce Durable Responses and Transient Cytokine Release Syndrome in Relapsed, Refractory CLL and ALL
    Porter, David L.
    Grupp, Stephan A.
    Kalos, Michael
    Loren, Alison W.
    Lledo, Lester
    Gilmore, Joan
    Milone, Michael C.
    Chew, Anne
    Levine, Bruce L.
    June, Carl H.
    BLOOD, 2012, 120 (21)
  • [10] CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS DIRECTED AGAINST CD19 (CTL019) INDUCE CLINICAL RESPONSES IN PATIENTS WITH RELAPSED OR REFRACTORY CD19+LYMPHOMAS
    Levine, B.
    Svoboda, J.
    Nasta, S. D.
    Porter, D.
    Chong, E.
    Lacey, S.
    Mahnke, Y.
    Melenhorst, J.
    Chew, A.
    Shah, G.
    Hasskar, J.
    Wasik, M.
    Landsburg, D.
    Mato, A.
    Garfall, A.
    Frey, N.
    Shaw, P.
    Marcucci, K.
    Shea, J.
    McConville, H.
    Manvar, N.
    O'Rourke, M.
    Lamontagne, A.
    Bersenev, A.
    Zheng, Z.
    Schuster, S.
    June, C.
    CYTOTHERAPY, 2015, 17 (06) : S13 - S13