The meningococcal vaccine candidate Neisserial surface protein A (NspA) binds to Factor H and enhances meningococcal resistance to complement

被引：0
|
作者：
Lewis, Lisa A. [1 ]
Ngampasutadol, Jutamas [1 ]
Wallace, Ruth [2 ]
Reid, Jane E. A. [2 ]
Vogel, Ulrich [3 ]
Ram, Sanjay [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA
[2] Trinity Coll Dublin, Dublin, Ireland
[3] Univ Wurzburg, Wurzburg, Germany
来源：
MOLECULAR IMMUNOLOGY | 2010年 / 47卷 / 13期
关键词：
D O I：
10.1016/j.molimm.2010.05.139
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
216
引用
收藏
页码：2243 / 2243
页数：1
相关论文
共 50 条
  • [11] Evaluation of Truncated NhhA Protein as a Candidate Meningococcal Vaccine Antigen
    Peak, Ian R.
    Srikhanta, Yogitha N.
    Weynants, Vincent E.
    Feron, Christiane
    Poolman, Jan T.
    Jennings, Michael P.
    PLOS ONE, 2013, 8 (09):
  • [12] Design of Meningococcal Factor H Binding Protein Mutant Vaccines That Do Not Bind Human Complement Factor H
    Pajon, Rolando
    Beernink, Peter T.
    Granoff, Dan M.
    INFECTION AND IMMUNITY, 2012, 80 (08) : 2667 - 2677
  • [13] A novel interaction between factor HSCR 6 and the meningococcal vaccine candidate GNA1870: Implications for meningococcal pathogenesis and vaccine development
    Ngampasutadol, Jutamas
    Welsch, Jo Anne
    Lewis, Lisa A.
    Jarva, Hanna
    Madico, Guillermo
    Vogel, Ulrich
    Visintin, Alberto
    Ram, Sanjay
    MOLECULAR IMMUNOLOGY, 2007, 44 (1-3) : 220 - 220
  • [14] Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance
    Griffiths, Natalie J.
    Hill, Darryl J.
    Borodina, Elena
    Sessions, Richard B.
    Devos, Nathalie I.
    Feron, Christiane M.
    Poolman, Jan T.
    Virji, Mumtaz
    MOLECULAR MICROBIOLOGY, 2011, 82 (05) : 1129 - 1149
  • [15] Engineering of factor H binding protein, a key vaccine antigen for the prevention of meningococcal disease
    Lavender, Hayley
    Lea, Susan
    Tang, Christoph
    NEW BIOTECHNOLOGY, 2014, 31 : S66 - S66
  • [16] Binding of Complement Factor H to PorB3 and NspA Enhances Resistance of Neisseria meningitidis to Anti-Factor H Binding Protein Bactericidal Activity
    Giuntini, Serena
    Pajon, Rolando
    Ram, Sanjay
    Granoff, Dan M.
    INFECTION AND IMMUNITY, 2015, 83 (04) : 1536 - 1545
  • [17] Impaired Immunogenicity of a Meningococcal Factor H-Binding Protein Vaccine Engineered To Eliminate Factor H Binding
    Beernink, Peter T.
    Shaughnessy, Jutamas
    Ram, Sanjay
    Granoff, Dan M.
    CLINICAL AND VACCINE IMMUNOLOGY, 2010, 17 (07) : 1074 - 1078
  • [18] Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen
    Malito, Enrico
    Faleri, Agnese
    Lo Surdo, Paola
    Veggi, Daniele
    Maruggi, Giulietta
    Grassi, Eva
    Cartocci, Elena
    Bertoldi, Isabella
    Genovese, Alessia
    Santini, Laura
    Romagnoli, Giacomo
    Borgogni, Erica
    Brier, Sebastien
    Lo Passo, Carla
    Domina, Maria
    Castellino, Flora
    Felici, Franco
    van der Veen, Stijn
    Johnson, Steven
    Lea, Susan M.
    Tang, Christoph M.
    Pizza, Mariagrazia
    Savino, Silvana
    Norais, Nathalie
    Rappuoli, Rino
    Bottomley, Matthew J.
    Masignani, Vega
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (09) : 3304 - 3309
  • [19] Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and Neisserial heparin binding antigen
    Vu, David M.
    Wong, Tracy T.
    Granoff, Dan M.
    VACCINE, 2011, 29 (10) : 1968 - 1973
  • [20] Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal Disease
    McNeil, Lisa K.
    Zagursky, Robert J.
    Lin, Shuo L.
    Murphy, Ellen
    Zlotnick, Gary W.
    Hoiseth, Susan K.
    Jansen, Kathrin U.
    Anderson, Annaliesa S.
    MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2013, 77 (02) : 234 - 252
12345