The Wilms' tumor gene WT1 is a common marker of progenitor cells in fetal liver

被引：11

作者：

Kanato, K

Hosen, N

Yanagihara, M

Nakagata, N

Shirakata, T

Nakazawa, T

Nishida, S

Tsuboi, A

Kawakami, M

Masuda, T

Oka, Y

Oji, Y

IJpenberg, A

Hastie, ND

Sugiyama, H ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Funct Diagnost Sci, Osaka, Japan

[2] Osaka Univ, Grad Sch Med, Dept Mol Med, Osaka, Japan

[3] Kumamoto Univ, Ctr Anim Resources & Dev, Div Reprod Engn, Kumamoto, Japan

[4] Osaka Univ, Grad Sch Med, Dept Canc Immunotherapy, Osaka, Japan

[5] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 326卷 / 04期

关键词：

Wilms' tumor gene; WT1; LacZ; fetal liver cells;

D O I：

10.1016/j.bbrc.2004.11.107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well known that the Wilms' tumor gene WT1 plays an important role in cell proliferation and differentiation, and in organ development. In this study, to examine the role of the WT1 gene in lineage determination, fetal liver cells from LacZ-transgenic mice, in which WT1 expression was marked by the expression of the LacZ gene driven by WT1 promoter, were FACS-sorted according to LacZ expression of high (LacZ(++)) or undetectable (LacZ(-)) levels, which paralleled endogenous WT1 expression levels. LacZ(++) fetal liver cells were enriched by hepatocyte and endothelial progenitor cells. These results indicated that WT1 expression is a common marker of both hepatocyte and endothelial progenitors. These results also implied a role of the WT1 gene in lineage determination. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：836 / 843

页数：8

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