Evaluation of the Long-term Administration of Rifaximin for More than Three Years in the Treatment of Repeated and Recurrent Overt Hepatic Encephalopathy

被引：2

作者：

Fujiwara, Yudai ^{[1
,2
]}

Suzuki, Kazuyuki ^{[1
,2
]}

Yusa, Kenji ^{[1
,2
]}

Eizuka, Makoto ^{[2
]}

Miura, Manami ^{[2
]}

Watanabe, Yuki ^{[1
,2
]}

Takahashi, Hiroshi ^{[2
]}

Takikawa, Yasuhiro ^{[1
]}

机构：

[1] Iwate Med Univ, Dept Internal Med, Div Hepatol, Yahaba, Iwate, Japan

[2] Iwate Prefectural Ninohe Hosp, Dept Gastroenterol, Ninohe, Iwate, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 07期

关键词：

rifaximin; liver cirrhosis; overt hepatic encephalopathy; hyperammonemia; PORTAL-SYSTEMIC ENCEPHALOPATHY; LIVER-CIRRHOSIS; PRIMARY PROPHYLAXIS; CARNITINE; ZINC; DIAGNOSIS;

D O I：

10.2169/internalmedicine.5793-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The patient was a 65-year-old man with alcoholic liver cirrhosis who had been admitted to hospital 5 times for repeated and recurrent overt hepatic encephalopathy (HE) despite numerous therapies, including disaccharide, branched-chain amino acid (BCAA) formula. L-carnitine and zinc. After the additional administration of rifaximin (1,200 mg/day orally), his consciousness level was well controlled for 3 years without any adverse effects. The long-term administration of rifaximin may be useful and safe for managing recurrent overt HE, although the maintenance dosage and duration of rifaximin and safety should be evaluated in patients with ameliorated HE.

引用

页码：1027 / 1033

页数：7

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