A new approach to phosphonate analogues of phosphatidyl derivatives

被引：0
|
作者：
Brel, VK [1 ]
Stang, PJ
机构：
[1] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Moscow Region, Russia
[2] Univ Utah, Dept Chem, Salt Lake City, UT 84211 USA
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 01期
关键词：
medicinal chemistry; allenes; alkenes; phospholipids;
D O I：
10.1002/1099-0690(200301)2003:1<224::AID-EJOC224>3.0.CO;2-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the preparation of the phosphonate analogues of phosphatidyl derivatives using a Horner-Mark [2,3]-sigmatropic rearrangement is described. Phosphonate analogues were prepared in which the sn-3 oxygen of the diacylglyceryl moiety is substituted by -HC=CH- or -CH2CH2- fragments.
引用
收藏
页码：224 / 229
页数：6
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