Does nitric oxide reduce fetal brain injury

被引：0

作者：

Di Iorio, R ^{[1
]}

Marinoni, E ^{[1
]}

Gazzolo, D ^{[1
]}

Michetti, F ^{[1
]}

Urban, G ^{[1
]}

Costantini, A ^{[1
]}

Andreano, T ^{[1
]}

Cosmi, EV ^{[1
]}

机构：

[1] Univ Rome La Sapienza, Lab Perinatal Med & Mol Biol, Rome, Italy

来源：

FETUS AS A PATIENT | 2000年

关键词：

D O I：

暂无

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

To verify whether nitric oxide supplementation is able to prevent brain injury in growth retarded fetuses, we have studied 19 pregnant women with IUGR fetuses randomly selected to receive either transdermal glyceryl trinitrate or placebo. Ten uncomplicated pregnancies matched for gestational age represented the control group. IUGR fetuses not treated showed higher concentrations of S-100 than control group whereas S-100 levels in treated IUGR fetuses were not different from control group, but they were significantly lower (p<0.01) than those found in not treated IUGR fetuses. Clinical outcome showed a reduction of brain dysfunction signs in treated fetuses. Reduction of S-100 protein levels in IUGR fetuses treated with NO demonstrates that improvement in utero-placental circulation may allow to prevent fetal abnormal haemodynamics response which causes brain damage

引用

页码：213 / 219

页数：7

共 50 条

[31] Nitric oxide from inducible nitric-oxide synthase does not exacerbate adriamycin-induced tubulointerstitial injury
Oteki, T.
Nagase, S.
Hirayama, A.
Ueda, A.
Yokoyama, H.
Yoshimura, T.
PROCEEDINGS OF THE XIII CONGRESS OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL, 2006, : 273 - +
[32] Nitric oxide does not modulate kainate receptor binding in human brain
Lees, RD
Slater, P
DSouza, SW
NEUROSCIENCE LETTERS, 1997, 233 (2-3) : 133 - 136
[33] Nitric oxide synthase (NOS) activity in the fetal llama brain submitted to hypoxaemia
Galleguillos, M
Valenzuela, MA
Riquelme, R
Sanhueza, E
Sánchez, G
Pastene, C
Figueroa, JP
Llanos, AJ
JOURNAL OF PHYSIOLOGY-LONDON, 2000, 523 : 110P - 111P
[34] Nitric oxide and the brain
Pelligrino, DA
Baughman, VL
Koenig, HM
INTERNATIONAL ANESTHESIOLOGY CLINICS, 1996, 34 (04) : 113 - 132
[35] Changes in the nitric oxide level in the rat liver as a response to brain injury
Ziaja, Marek
Pyka, Janusz
Boczkus, Bozena
Plonka, Beata K.
Plonka, Przemyslaw M.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2011, 25 (04): : 423 - 430
[36] INTERPLAY BETWEEN NITRIC OXIDE, MITOCHONDRIA, AND GLUTAMATE UPON BRAIN INJURY
Vaglio-Garro, Annette
Hosmann, Arthur
Weidinger, Adelheid
Kozlov, Andrey V.
FREE RADICAL BIOLOGY AND MEDICINE, 2024, 218 : 9 - 9
[37] The role of nitric oxide in reoxygenation injury of brain microvascular endothelial cells
Nagashima, T
Wu, S
Ikeda, K
Tamaki, N
BRAIN EDEMA XI, 2000, 76 : 471 - 473
[38] Changes in nitric oxide content following injury to the neonatal rat brain
Ziaja, Marek
Lubieniecka, Jolanta
Lewicka, Michalina
Pyka, Janusz
Plonka, Przemyslaw M.
BRAIN RESEARCH, 2011, 1367 : 319 - 329
[39] Effects of a thermal injury on brain and blood nitric oxide (NO) content in the rat
Lestaevel, P
Agay, D
Peinnequin, A
Cruz, C
Cespuglio, R
Clarençon, D
Multon, E
Chancerelle, Y
BURNS, 2003, 29 (06) : 557 - 562
[40] Melatonin regulates nitric oxide synthase expression in ischemic brain injury
Koh, Phil-Ok
JOURNAL OF VETERINARY MEDICAL SCIENCE, 2008, 70 (07): : 747 - 750

← 1 2 3 4 5 →