Synthesis of new quinoline fused heterocycles such as benzo[h]-1,6-naphthyridines and pyrazolo[4,3-c]quinolines

被引：27

作者：

Ghotekar, Bhausaheb Kedarnath ^{[1
]}

Ghagare, Maruti G. ^{[1
]}

Toche, Raghunath B. ^{[1
]}

Jachak, Madhukar N. ^{[1
]}

机构：

[1] KTHM Coll, Dept Chem, Organ Chem Res Ctr, Nasik 422002, Maharashtra, India

来源：

MONATSHEFTE FUR CHEMIE | 2010年 / 141卷 / 02期

关键词：

Nucleophilic addition; 4-Aminoquinoline-3-carboxylates; Cyclocondensation; Sodium dithionite; Reduction; Spectroscopy; ANTIMICROBIAL ACTIVITY; POLYMER MATRICES; ANTIMALARIALS; DERIVATIVES; INHIBITORS; DESIGN; AGENTS; ESTER; ACIDS;

D O I：

10.1007/s00706-009-0236-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of novel benzo[h]-1,6-naphthyridines was successfully achieved by cyclocondensation of ethyl 4-aminoquinoline-3-carboxylates with malononitrile. The pyrazolo[4,3-c] quinolines were synthesized by nucleophilic substitution and subsequent addition reaction of ethyl 4-chloroquinoline-3-carboxylates with different hydrazines. All new compounds were characterized by spectral and analytical methods.

引用

页码：169 / 175

页数：7

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