Acid-Catalyzed Cascade Reactions of Enaminones with Aldehydes: C H Functionalization To Afford 1,4-Dihydropyridines

被引：63

作者：

Yang, Jingyu ^{[1
]}

Wang, Chengyu ^{[1
]}

Xie, Xin ^{[1
]}

Li, Hongfeng ^{[1
]}

Li, Yanzhong ^{[1
]}

机构：

[1] E China Normal Univ, Inst Med Chem, Dept Chem, Shanghai 200062, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Nitrogen heterocycles; Cyclization; Lewis acids; C-H activation; Domino reactions; SOLID-STATE SYNTHESIS; POLYSUBSTITUTED PYRROLES; COMBINATORIAL SYNTHESIS; CYCLIZATION REACTIONS; BETA-ENAMINONES; AROMATIC IMINES; DOMINO REACTION; ONE-POT; ARYLATION; 3-COMPONENT;

D O I：

10.1002/ejoc.201000607

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient acid-catalyzed approach to the synthesis of functional 1,4-dihydropyridines from the reaction of readily available enaminones with aldehydes has been developed. This methodology was realized by a cascade reaction involving first formation of divinylmethanes and subsequent intramolecular cyclization

引用

页码：4189 / 4193

页数：5

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