Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment

被引：65
|
作者：
Garcia-Echeverria, Carlos [1 ]
机构：
[1] Sanofi Aventis, Oncol Drug Discovery, F-94400 Vitry Sur Seine, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 15期
关键词：
Kinase inhibitors; mTOR; Anticancer agents; MAMMALIAN TARGET; RAPAMYCIN; PATHWAY; DISCOVERY; TYROSINE; COMPLEX; POTENT; PI3K;
D O I：
10.1016/j.bmcl.2010.05.099
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Over the past few years a number of components of the PI3K/mTOR pathway have been the subject of intense drug discovery activities both in pharmaceutical companies and in academia. This review article summarizes progress made in the identification and development of allosteric and ATP-competitive kinase inhibitors of mTOR and their potential therapeutic use in oncology. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4308 / 4312
页数：5
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