Transcriptome variation in human populations and its potential application in forensics

被引:4
|
作者
Daca-Roszak, P. [1 ]
Zietkiewicz, E. [1 ]
机构
[1] Polish Acad Sci, Inst Human Genet, Strzeszynska 32, PL-60479 Poznan, Poland
关键词
Transcriptome variation; Human population identification; Laser capture microdissection; Forensic identification; LASER CAPTURE MICRODISSECTION; GENE-EXPRESSION VARIATION; DNA METHYLATION; REGULATORY VARIATION; HUMAN AGE; HUMAN IDENTIFICATION; MESSENGER-RNA; ANCESTRY; MARKER; ASSAY;
D O I
10.1007/s13353-019-00510-1
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
This review presents the state-of-the-art in the forensic application of genetic methods driven by the research in population transcriptomics. In the first part of the review, the constraints of using classical genomic markers are shortly reviewed. In the second part, the developments in the field of inter-population diversity at the transcriptomic level are presented. Subsequently, a potential of population-specific transcriptomic markers in forensic science applications, including ascertaining population affiliation of human samples and cell mixtures separation, are presented.
引用
收藏
页码:319 / 328
页数:10
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