Safety and clinical activity of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC)

被引:10
|
作者
Antonia, Scott [1 ]
Rizvi, Naiyer [2 ]
Brahmer, Julie [3 ]
Ou, Sai-Hong [4 ]
Khleif, Samir N. [5 ]
Hwu, Wen-Jen [6 ]
Gutierrez, Martin [7 ]
Schoffski, Patrick [8 ]
Hamid, Omid [9 ]
Weiss, Jared [10 ]
Lutzky, Jose [11 ]
Maio, Michele [12 ]
Nemunaitis, John [13 ]
Jaeger, Dirk [14 ]
Balmanoukian, Ani [9 ]
Rebelatto, Marlon C. [15 ]
Steele, Keith E. [15 ]
Jin, Xiaoping [15 ]
Robbins, Paul B. [15 ]
Blake-Haskins, John A. [15 ]
Segal, Neil H. [16 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
[2] Columbia Univ, Med Ctr, New York, NY USA
[3] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA
[4] Univ Calif Irvine, Sch Med, Irvine, CA 92717 USA
[5] Georgia Regent Univ, GRU Canc Ctr, Agusta, MD USA
[6] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[7] Hackensack Univ, Med Ctr, Hackensack, NJ USA
[8] Leuven Canc Inst, Leuven, Belgium
[9] Angeles Clin & Res Inst, Los Angeles, CA USA
[10] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[11] Mt Sinai Med Ctr, New York, NY 10029 USA
[12] Univ Hosp Siena, Siena, Italy
[13] Mary Crowley Canc Res Ctr, Dallas, TX USA
[14] Univ Heidelberg Hosp, Natl Ctr Tumor Dis, Heidelberg, Germany
[15] Medlmmune, Gaithersburg, MD USA
[16] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
关键词
D O I
10.1158/2326-6074.CRICIMTEATIAACR15-A047
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A047
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Compare the efficacy and safety of programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) inhibitors for advanced non-small cell lung cancer: a Bayesian analysis
    Liang, Jiaqi
    Li, Ming
    Sui, Qihai
    Hu, Zhengyang
    Bian, Yunyi
    Huang, Yiwei
    Zhan, Cheng
    Jiang, Wei
    Wang, Qun
    Tan, Lijie
    TRANSLATIONAL LUNG CANCER RESEARCH, 2020, 9 (04) : 1302 - +
  • [32] Efficacy, safety and tolerability of MEDI4736 (durvalumab [D]), a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib (G): A phase I expansion in TKI-naive patients (pts) with EGFR mutant NSCLC
    Gibbons, D. L.
    Chow, L. Q.
    Kim, D-W.
    Kim, S-W.
    Yeh, T.
    Song, X.
    Jiang, H.
    Taylor, R.
    Karakunnel, J.
    Creelan, B.
    JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (04) : S79 - S79
  • [33] An immunohistochemical PD-L1 companion diagnostic assay for treatment with durvalumab (MEDI4736) in NSCLC patients
    Rebelatto, Marlon C.
    Mistry, Amita
    Sabalos, Constantine
    Schechter, Nicole
    Walker, Jill
    Midha, Anita
    Steele, Keith E.
    Robbins, Paul B.
    Li, Xia
    Shi, Li
    Blake-Haskins, John A.
    Ibrahim, Ramy A.
    Richman, Laura
    CANCER IMMUNOLOGY RESEARCH, 2016, 4 (01)
  • [34] Safety and efficacy of durvalumab (MEDI4736) plus tremelimumab in advanced non-small-cell lung cancer (NSCLC)
    Karakunnel, Joyson J.
    ANNALS OF ONCOLOGY, 2016, 27
  • [35] The prevalence of programmed death ligand-1 (PD-L1) expression in non-small cell lung cancer in an unselected, consecutive population
    Skov, Birgit Guldhammer
    Rorvig, Sara Bird
    Jensen, Thomas Hartvig Lindkaer
    Skov, Torsten
    MODERN PATHOLOGY, 2020, 33 (01) : 109 - 117
  • [36] Immunotherapy efficacy of programmed cell death 1 (PD-1) versus programmed death ligand-1 (PD-L1) inhibitors in non-small cell lung cancer (NSCLC) patients: A systematic review and meta-analysis.
    Yang, Danrong
    Cui, Longgang
    Zhang, Yuzi
    Zhao, Zhengyi
    Bai, Yuezong
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [37] Spatiotemporal Effects on Programmed Death Ligand 1 (PD-L1) Expression and Immunophenotype of Non-Small Cell Lung Cancer (NSCLC)
    Kowanetz, Marcin
    Koeppen, Hartmut
    Boe, Marigold
    Chaft, Jamie E.
    Rudin, Charles M.
    Zou, Wei
    Nickles, Dorothee
    Desai, Rupal
    Nakamura, Rin
    Sandler, Alan
    Amler, Lukas
    Hegde, Priti
    Rizvi, Naiyer A.
    Hellmann, Matthew D.
    JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) : S199 - S199
  • [38] Programmed cell death ligand-1 (PD-L1) as a biomarker for non-small cell lung cancer (NSCLC) treatment-are we barking up the wrong tree?
    Dempke, Wolfram C. M.
    Fenchel, Klaus
    Dale, Stephen P.
    TRANSLATIONAL LUNG CANCER RESEARCH, 2018, 7 : S275 - S279
  • [39] Diverse cutaneous adverse eruptions caused by anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies: clinical features and management
    Shen, John
    Chang, Jason
    Mendenhall, Melody
    Cherry, Grace
    Goldman, Jonathan W.
    Kulkarni, Rajan P.
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2018, 10
  • [40] Programmed death ligand-1 expression in non-small cell lung cancer
    Velcheti, Vamsidhar
    Schalper, Kurt A.
    Carvajal, Daniel E.
    Anagnostou, Valsamo K.
    Syrigos, Konstantinos N.
    Sznol, Mario
    Herbst, Roy S.
    Gettinger, Scott N.
    Chen, Lieping
    Rimm, David L.
    LABORATORY INVESTIGATION, 2014, 94 (01) : 107 - 116