In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

被引：50

作者：

Shi, Limin ^{[1
]}

Yan, Chenxu ^{[1
]}

Ma, Yiyu ^{[1
]}

Wang, Ting ^{[1
]}

Guo, Zhiqian ^{[1
]}

Zhu, Wei-Hong ^{[1
]}

机构：

[1] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Funct Mat Chem, Inst Fine Chem,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 82期

基金：

中国博士后科学基金;

关键词：

STRATEGY;

D O I：

10.1039/c9cc06869d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we developed a dual-channel and light-up near-infrared fluorescent probe for ratiometric sensing of beta-galactosidase (beta-gal) activity. The well-designed probe, which shows ratiometric optical response with a significant red-shift (from 575 nm to 730 nm), was successfully applied to detect endogenous beta-gal activity in SKOV-3 cells and tumor-bearing mice.

引用

页码：12308 / 12311

页数：4

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